Tyson/Dave is the one I'm really invested in and is my favorite dynamic all around. The bond between them is just so rewarding to watch deepen, be it romantically or platonically. I just want them in each other's life. (After some much needed character development on both sides of course.)
His is my favorite route, favorite character, best only pairing with Dave, makes me feel the widest range of emotions to boot. Just an all around flawed and tragic but likeable character.
The only one besides Benson I safely classify under "protect at all costs".
A bit less serious, but I guess Jack/his knife. I really hope to get a chance, as a player, to introduce the two of them further at some point. Memphis/knife is another good one. All villains need to meet knife. Slowly. Very slowly.