Game will randomly just lock up during an AI turn, no crash, no error message, just totally freeze up with a partially filled "turn bar", animations of resources and stuff continue in the background indefinitely.
Same issue for me. Usually I can get by it by reloading the game, but finally ran into one where it won't load my save file at all.
Drawing quite a bit of RAM as well (averaging over 17GB).
Still love the game though and looking forward to playing more.