I know this version of macOS broke a lot of things, so yes, it's possible the game isn't compatible with it. Thanks for reporting this, I'll investigate the issue with the developer of the engine. Could you provide any additional information? Does it crash at launch, do you get a specific error?
As you can see, I'm told the application may be damaged, and in the Finder it shows the circle-bar symbol over the app.
My bad, it seems like I totally botched the previous update and some files are missing from the macOS folder, possibly because of a file export problem. My guess is Mac users of the first version weren't affected because Itch's update system didn't remove said files. This is actually good timing because I was about to release a new version with a Dutch translation and a few minor tweaks. Thanks for pointing this out, I'll release a fix in a day or so.