Upon further experimentation, I realize that the shader must have a solid color to draw over, even if the shader is applied to a greater area it will not glitch anywhere that is transparent. I can work around this, thank you for the amazing shader!
The shader is only meant to be applied on surfaces, though you might have luck with sprites, assuming they're on their own separate texture page and provided there's enough empty space around them for the various texture shifting effects to be properly rendered. Also, the shader will work just fine with or without standard alpha blending, there aren't any special requirements in regards to that.