Thank you so much, especially for the constructive feedback!
I'm actually working on adding a bit more structure to the runs at the moment, turning it into a finite length experience.
Currently the run will end after 20 days, meaning the builds won't be able to get quite as insane but you'll still have plenty of time to explore options.
After completing a run you'll be able to increase your mastery level which adds a new layer of difficulty (new enemy types, less player health etc.).
Hopefully this will let less experienced players dig their teeth into the talent tree while offering a serious challenge to players who want to push the game to its limits.