No, I just tried again right after crash. The reason I have written a comment first and sent crash report via app was I had some issues with other games in the past, so I just though it will not run. I am glad I checked again.
I cannot help too much with Mac / Big Sur specific issues now except just checking a new build if you make one and ask me.
I am planning to resume my gamedev efforts soon, so maybe then I will have to dig more with my own projects.
I cannot find now the link to the report and I guess there is no UI for viewing them on Itch. There was some "stack trace" referring to a bunch of files, not sure if they were related to some parts of Itch's app or the game though. Do not have any response from Itch team yet.