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In patient zero after about 30 seconds silent assassin is auto lost. 

I can reproduce that. The issue is that you seem to automatically kill a NPC named "Takai Janpu". Possibly IOI left the poor guy out of bounds or clipped within a wall?

Not sure how to fix that without doing mission-specific tweaks, though. I'll have to think about it. Thanks for the report!

That's hilarious and nice to see you were able to track it down.