@Cairn4, I just wanted to point out something that might help with the troubleshooting. The mouse seems to be working fine within the game (when the problem is experienced) due to the fact that objects on the screen are still detectable. The reason why I say this, is during gameplay, the mouse cursor is normally white. This will change to Yellow when it moves over an object like ORE/ICE or FRUIT. This tells me that the game recognizes objects but the click function just isn't operable. Hope this helps a little...