Feel like it needs an option to turn the auto-buy stuff off for a bit, if there is one I can't find it. The auto-buy atoms in particular is absolutely killing me, I can't buy anything until every single atom for each unlocked element has reached that price.
Also, wish it was more clear how to unlock the power room. I was at like 9% efficiency in my first run before I left, came back and noticed more power generation was available. Dunno how close I am in the second run, partially because the atom auto-buy is making things take forever.