Another version of the "Charge does count as an item use" bug. Just had a poison enchanted Whiplash instakill an enemy because his Axe got charged 5x at the start of combat which caused it to trigger my whiplash 5x with scaling +x poison per trigger due to the other stuff I had going on, which also charged my blade causing it to trigger a bunch of times. So he just got instant 300+ Poison. Overall Poison seems to be the most force-able build currently. Basically guaranteed 10 wins. I had an absolutely atrocious start and didn't actually get poison items in any shop until I was at 1 life, but then just win steaked from there.
