I like the idea of each item having a secret debuff you don't know until later.
It did seem like I was better off not collecting items though and skipping enemies when I can. When I started doing that, it made it where I had enough health and defense to finally defeat the boss. There might need some stat rebalancing done so its actually worth engaging with those game mechanics and still survive.
Also, it was tricky to keep track of which collected item was doing what curse/debuff.
Overall, nice job! I like the classic first-person dungeon crawler style and the look of the eye-monster boss. Nicely done.