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I downloaded the latest build about 3 hours ago. I don't get a Windows Defender threat detected when I scan but I did initially get a warning from Firefox when I downloaded the file and a warning from (I think) Windows Defender when I first ran the exe. I can't replicate now, presumably because I told Windows Defender to not worry about it.

In contrast to OP's issue these sound like the standard messages you would get when trying to download any executable -- my assumption is downloading another game from itch would result in the same warnings, assuming the game was very new or otherwise infrequently downloaded.