Some general/universal coding advice that I can give is to use comments creatively to creation "Sections. Break up your code into sections that make sense to you so you can work faster/easier.
Personally, for work (and for ren'py) my code will have a lot of section headers like "#----------------------Such n Such Variables---------------------------".
Make them as wide as you want for visibility. You could also have long headers as "Primary Sections" and then have shorter ones insider as "Sub-Sections". Also, as a rule of thumb I say to separate specific lines of code by two spaces, to make it more visually obvious that "this is not part of that". In Ren'Py specifically I use a variation of these technique to visually group "rooms" as seen below:
"#-----------------------------MC House - Upstairs Bedroom One----------------------------------"
etc.