Thanks for that. I will take a look and get this sorted.
Poking around a bit more, I've found the issue. Most enemies have a 'wrong answer penalty', a huge nerf to damage (sometimes -90%) if the player doesn't have the exact intended build equipped. This is incredibly unfun; instead of it being a game of trying to make a build that beats the challenge ahead of you, it's a game of trying to guess a secret code that the developer left cryptic hints about.
If the player can devise a non-standard build that works, either through unexpected interactions or brute force, you ought to let them. Giving a huge nerf whenever the player doesn't do exactly what you wanted them to do is just bad game design.