This one gets the award for: Closest A Toxic Yuri Jam Game Got to Actually Making Me Throw Up
This thing is intense from start to finish and does things with its engine that should not be possible. The art is gorgeous, and it has some of the most unique monster designs I've ever seen. The demons appearing differently to each person, and the way that fact is used in the story, was an extremely effective touch. I could probably read this game ten times and continue to find new metaphors and subtle things I missed each time. Truly incredible.