Super cool roguelike! I love how much each run can be different by just changing different rules. My build was melee focused, and I ran into a problem where since I'd be spamming left click, the affix menu would pop up and I'd just click one randomly since my cursor would already be over a button.
Still, this was a super unique take on a roguelike, with having to spend your time to get upgrades (which would end up being my downfall, since I got a little too greedy with melee damage increases >:) )