Does anyone know how to have sex with at least one person, or even with Guillermo? It’s been days and I don’t have a partner 😭..
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Skill issue.... but in all seriousness, I just flirt constantly with those I'm interested in. If you get their lust high enough, and their inclinations allow for it, you can eventually get in the pants/skirt. You can also just do "Booty Calls" via texting people you have the phone numbers of. Just, again, ensure that they have the appropriate lust value(I've even had luck with just 1/4 lust bar) and inclinations.
EDIT: Of course, this is just in reference to random students. Those with storylines, such as your starting Best Friend and the Classroom Harasser, can only have sex with after a certain point. You can go to the wiki to find out more about the storylines, though I'm fairly certain it is out of date.