Dang thats polished. Very nicely done. Great animations and transitions and feedback for user input. I didn't get the hang of bigger reactions or get past the 3rd level but I'd love to see power ups or special tiles that increase the range of reactions. Something to keep mixing it up once you've figured out the optimal pattern for standard tiles.
Edit: I got it now, also I misunderstood the run system. Still awesome game. I could get hooked on this, especially if it were longer.