The game isn't that hard, you just need a little luck at the start and an item that gives you about +17 attack this turn. You don't think it's that simple, do you? In endless mode, defeat is guaranteed. At level 45, by my calculations, your health is just going down the drain, and items... about +600 attack damage this turn? Seriously? The worst part is that even items don't save you. The only ones that can theoretically give you +1 floor are the Amulet of Immortality and the Scroll of Wisdom, the other four are pure crap. I think inevitable death shouldn't be a thing in endless mode. It's very simple to do; you just need to get the same stat growth as before floor 40.
