Oh my, hello! I didn't think you'd see my comment lol, but anyways. As someone who desires to live by princess treatment, I really love Isaac's route tje most. Although, Simon's and Anthony's route are really good since it gives us a lot of things to do, which make sense in the story. Like, trying your best to not let Simon experiment on you lol.
I play with the choices a lot, so I can't really say if I prefer an OC MC, or self-insert. As the choices I make are very different in those 2. But I did make an OC MC, so I'm kinda leaning more towards that. With an OC MC I ended up on either Anthony/Simon's route, as the character I made wants to be free, and is willing to do things to help people/find cure. With self-insert, I end up on Isaac's, with the reason I already said.
Thank you again, for this wonderful game! I hope you have ever more wonderful days.