i was in the dungeon north east of Silverpine, hade low health, made a quicksave by the stares and was gonna rush to grab stuff. a giant frog killed me so i reloaded and tried to run past it, one of its bubbles gott me and i quickly loaded. when i loaded my character took damage from nowhere and reached 0 health, I didnt die and the game just stopped responding (not froze, everything was moving around like normal i just didnt have the ability to move or open inventory)
Edit: i should add that loading it again did fix it. but damage did carry over into a load for some reason
Oh, that reminds me, I've had similar but not identical occurrences when a projectile was heading in my direction, generally from a slime, and I attempted to move to another tile.
It seems projectiles trying to follow you through tiles causes unplanned freezes, this is probably what happened here as well, loading must act like changing tiles.