Respectful, non-toxic, constructive feedback:
The aesthetic is inconsistent and it's hard to tell what I'm supposed to feel, I think you should choose one of cute/horror and more subtly introduce elements of the other rather than cancerously mashing both together. I understand that the style you're going for is supposed to be eclectic, but this impression would be enhanced if interfaces were easier to understand. The best way to improve the UI would be to use more normal and readable fonts, and keep the fancy fonts only for large/decorative text. Also remember to have a lot of contrast between text color and background color.
The unusual dialogue blips are distracting and weird especially at the beginning when you should be carefully introducing the player, maybe only use them occasionally for emphasis on certain lines or for joke characters.
While there are a lot of variations, the main character sprite is mediocre in my opinion, since this will be the main selling point of the game I think it's worth improving your art style.
The minigames are interesting and there's quite a variety of crazy things you can do, this part was done well. I wonder if there could be something more to this game, like some kind of long-term goal to justify what you're doing and to make her feel more like a real character you're torturing rather than a sprite with rapidly fluctuating statuses. Games like Needy Girl Overdose have day phase cycles and long-term progression, I think this game is missing something like that. Also, it could add to the sense of reality if you added a location system so she can travel to different places, and maybe she has to do other things during the day like eat and sleep and isn't always available to smoke weed or be shot in the head. Something basic and crude could still add a lot, it doesn't have to be like NGO.