Maybe the game folder is in a protected pc area?
The game needs permission to be able to create the xml files to save.
Does the game not leave the adult game warning scene?
Does the game play music?
I have run into this problem with other games using some versions of Unity (especially Unity 2017) no matter where the game is installed. I have seen this also with games on Steam using some versions of Unity particularly when the Mac has an AMD graphics card.
The adult warning page comes up and can be clicked away. Then the start or new game page comes up and all of the buttons appear to work (the mouse over causes them to change). I click on new game and some dialog buttons appear, NEW GAME, FILE NAME, CONFIRM, CANCEL. I then type in a name for the game and hit confirm and nothing happens although the picture in the background is still scrolling/moving. No music at all.
UPDATE: I spent a little time going thru some of the unix files and found a couple of places where there are syntax errors noted. So if you use Unity 2017 plus some syntax errors, that may be the issue causing the game not to start up.
I put the save file into the game package contents. I entered the name of the game into the file name, SavXXX, for the game into the file name but nothing happened until I right clicked on the saved file name. It then showed a group of buttons that looked like an old telephone dial pad (hero, relationship, inventory, & quest) and information at the top of the page concerning character assets (food, water, light, moral, clock, & day)). I could click on the items in the dial pad but nothing would go forward from there. Was there a specific location that I should have put the save file folder? Also, when I start the game initially Your game always asks to connect to the web. Is that a requirement for the game to run??