Fun! The boss battle catching me off-guard with some resources and no way to craft them was killer in my first run; next time I got to the boss I had stockpiled 5 of every card I wanted to use plus some extra chaos... didn't even get to using one of each XD The onslaught of enemies before the endgame is much harder than the final battle (though with the "can you survive until the final enemy?" bit on the win screen, it makes me think this is intentional, and I'm guessing there's actually an end to what I had assumed to be endless foes!)
My main strategy was "always avoid the catacombs" because it's REALLY easy to get bone dust elsewhere and it's not all that useful (well I mean it's in the healing card but you need 2x as many mushrooms which are much harder to get and much more versatile). I had an abundance the whole game. Can't even use 'em up quickly on chaos cards, since 3x bone dust makes smolder.
Now of course my play style almost certainly affected how useful I found each resource. Especially when trying to farm resources so one of your slots is taken up by efficiency, when you're pouring everything into regen and haste, there's not a whole ton to do with bone dust.