Maybe I'm just dumb, but I can't figure out any "strategies" and always get my ass handed to me in any genocide run, I have to level red to at least 50 to deal with the slime queen, not to mention the constant barrage of mechs (can be avoided with the double-move item and breaking 2 enemies in one turn), but you can't out-damage them and out-draining is also not an option, especially when you and them are all at level 100