Ran my first Lancer game a few days ago online with the group I usually play with in person, and it translated extremely well to online play. Comp/Con is a beautiful and unique tool for players that is both intuitive and responsive, and the encounter builder/mission runner accompanies it really well. By the end of the session, most of the players had set up their webcams with cockpit backdrops because they were that into the game. With two weeks of prep and a 15-20 minute brief for a group of veteran role players, we were ready to go. It's a great system, a great world, and I really look forward to more from the world of Lancer in the future.
P.S. The Long Rim is also a great setting!