If anything, I think the one update where it makes the most sense more than anything would be London and Dizzy's, since their biggest goal is making girls larger and larger. After all, I think while exploring the facility you can encounter a "hangar-like" chamber, with a woman (probably larger than the ones the player feeds.) is getting tube fed a shiny formula. Maybe that could be the natural evolution of the Blob stages.
If they aren't supposed to be the same in size and proportions as our own girls that is.