You can use talents or equipment to discard a card on a draw. Usually this is done to get rid of a bad card. It seems unlikely, but once in a while a player will decide to discard a good card because they think that it's better for the whole group to face a bunch of zombies or something than to activate a particular condition that they aren't ready to reveal. Mainly, the negative effects of 2-6 are just a motivator to draw more cards to get more conditions into play.