Thanks for playing! The first minigame relies on waiting until after the VO has finished providing each direction, and then clicking on the button/lever instructed. For the sliders and levers, there's no need to click and drag, just a standard left mouse click.
Each of these spots should be clickable after the VO gives the instruction, in this order:

Please let us know if that's not working, it works when we test it on our end, but we'd love to catch and fix any bugs or problems!