There's definitely some imbalance in the game, but it's very fun. What I'd come up with:
- Mirror with retain transient rune
- Getting the add runes and doing druid with root + amass transient rune
- Trident + compass rose + glass chalice relics
Very momentum-y, use the slow turns to find mirror and get some extra energy next turn with trident, then line up compass rose with mirror/druid and deal some crazy damage. Got all this in I think 3 or 4 prestiges, dealt like 3k damage in 1 turn on Ebony Void when it all aligned.