Yeah sure you could, this is done in Blender, idk if you can get the same look in a game engine. Try it out!
Not quite 100%... rim & highlight aren't quite there & the painterly effects aren't as strong as I'd like. But not bad. May just be down to lighting model but I'm sure it's possible, if I were a bit more experience haha.
Looks nice, keep it up 👍