Might try a run where I max out all of the curses just to see, but am probably just going to experience 0 willpower hell.
Yeah, if you get too many curses, you basically end up on rails of just cycling between various compulsory actions e.g. forced to cycle through your various sugar daddies day after day, to the point where you may only actually get to play one in a few days (or potentially not at all, I suspect, if you end up with 5-7+ full curses).
Personally, I wish there was a way to remove or reduce most full curses, just so you have a shot at keeping your playthrough manageable if you end up "collecting them all"
Honestly I just finished my defeat playthrough, and the only curses I ever picked up were the full power Lust and the weakened Greed. It didn't matter in the slightest, as I started literally every single day at 0 willpower. There seems to be some form of cooldown interestingly, as it would only force me to choose one of the sugar daddies every 3-4 days.