Might try a run where I max out all of the curses just to see, but am probably just going to experience 0 willpower hell.
Yeah, if you get too many curses, you basically end up on rails of just cycling between various compulsory actions e.g. forced to cycle through your various sugar daddies day after day, to the point where you may only actually get to play one in a few days (or potentially not at all, I suspect, if you end up with 5-7+ full curses).
Personally, I wish there was a way to remove or reduce most full curses, just so you have a shot at keeping your playthrough manageable if you end up "collecting them all"