If you mean hide the game while it's active, I believe there's an option in-game to set the window to "windowed mode" and you can tab out of the game, leaving just the game's icon on your taskbar. :P
Viewing post in Messy Academy (abdl diaper vn) v0.21 comments
If you right-click the program/app > properties. In the shortcut tab, there's a option "change icon" and that'll let you change what icon is displayed to whatever you wish. :P You could possibly rename the program too, but that might cause issues with the game launching correctly? (Haven't tried it.)
Other options include, making a folder and hiding certain program/apps in said folder or there's probably various other methods to hide stuff better than that. (I'd check Youtube for that though.)