It seems to me that the game is not very good as a novel (although I don't really understand novels and can't call my opinion authoritative)). Yes, it has an interesting visual style, etc., but all the characters are built around one trait of their personality. The main character's sister is just the main character's sister and nothing more, Horu is the main character's wife and nothing more, Axton is a mad scientist (and all that follows). That is, they don't have any individuality that makes them alive. (And in general, they are rather empty templates of their images)
In addition, given what was said earlier and the overall density of actions in the game, their actions seem far-fetched and unnatural, that is, in the first scene Axton already considers the main character almost a brother, in the next one it already makes him almost kill a person, etc. Or a tragic scene with the infection of the main character's sister. It seems like a dramatic scene, but on the other hand, the sister herself is not perceived as a living character, and we know about their relationship with the main character only from literally 2 30-second inserts with a backstory. Horu's reaction to this seems to be all the more played. The player only knows about her relationship with the main character's sister that she:
The main character's good wife -> loves her sister-in-low
(I don't pretend to be expert and I don't want to offend anyone if anything)