TL;DR: this is something that happens with every itch.io game, windows is so annoying
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Not exactly, what you are probably referring to is lack of electronic code signature. Which is typical for projects released here because it’s expensive to do and itch is a platform full of first time indies. And without codesign Windows shows a protective warning.
Here the issue is different, but curiously if the executable was codesigned, it might have lowered the risk factor for the AV software and prevented the false positive.