Really good set up, lots of satisfying details and levels of interactivity like having to shoot at boxes to gather pickups instead of simply walking into them. The isometric view with buildings and environmental details looks great but as it's 2D, I'd have loved for the buildings in front of the player to have some temporary opacity, which also becomes a great way to hide special items/ encourage exploration.
I also think having a little bit more speed from the start would add a bit of 'punch' to the gameplay and add some intensity. I like it! Good luck to you.