I'm so sorry for your inconvenience, have you try clicking on "More Info" and then click on "Run Anyway" after the Windows Defender warning appeared? In my case, this will solve the problem.
And if you want to play this game on the browser, try clicking a blue fullscreen button at the bottom right of the game screen after you clicked the "Run game" button, this way will make the game enter a fullscreen mode and you can play the game normally.