If you have Steam installed (+Proton), you can
- Download and unzip Descending
- Click on "Games" in the toolbar (at the top of the client)
- Click "Add a non-steam game to my library"
- Browse for and select "Descending.exe"
- Navigate to the game in your library
- Select "Properties", then "Compatibility"
- Check "Force the use of a specific Steam Play compatibility tool"
- Select a Proton version (I used "Proton 9.0-4")
- Launch the game from steam!
You can do this for most games that doesn't have a linux port.