This would be amazing! Please do! I have played Pentagruel as a sci-fi game, fielding most of my force with Muskets, snipers with Bow & Arrows and then a tank as an Ogre Chariot!
When I first started working on Pentagruel, I planned to title it Mincemeat, with a sci-fi variant called Meatgrinder. I didn't get round to it in the end, but from my notes the main things that would need rules for that Pentagruel doesn't currently allow for are explosives and vehicles.
I can't wait to see what you come up with! If you do put together any specific solo rules please share those as well, I've had a few people recommend adding a solo variant, but as I've never played any solo wargaming I wouldn't know where to begin!