Thanks. As for your question Logazor, this account is basically an archive, I very rarely login to check it anymore because it's not like there will be updates.
Whether it's safe to update mid-game depends on, a, where you're currently at and what parts of the AIO you're using and, b, what version you're trying to update from. Going from 1.0 to 2.5 for example isn't a good idea, but if all you want is a few companion fixes and the like, yes, it'll be okay.
To give you an idea, if you're currently in the open world with some followers and not in the middle of one of the custom quests for example, it's safe.