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Ah, that’s an interesting question!  

Here’s the rough ranking of alcohol tolerance: Caeran < Bryant < Aris < Deacon

And here’s why:

Aris： inherited his mother’s high alcohol tolerance, and as a kid he was even trained to drink for social occasions. Still, he doesn’t like the taste, and once he reached the Middle Layer he couldn’t afford liquor anyway.

Bryant： his whole family handles alcohol poorly. In the main story he smokes and drinks, but that’s pure self-destruction under pressure. Normally he keeps tight control over any vice and gets drunk after half a glass.

Caeran： loved alcohol before he acquired his power. After the awakening, even a small intake sends his hormones into chaos, and because his ability demands microscopic precision, the booze he once adored became a lethal weakness.

Deacon：loathes tobacco and liquor and would never touch them voluntarily. Unfortunately the lab retro-fitted his body with extreme self-healing: the instant ethanol enters his system it’s flagged as a hostile substance and broken down. Result: an involuntary, unbeatable drinking champion.