Fun concept ! That's a nice entry, I liked the graphic style, and the trivia questions too. The anomalies are fun and well explained, the idea is good and well executed. I really enjoyed playing it !
Possible improvements for me :
Like others, I struggled on the color change, maybe go for a complete color change ? (Or maybe I'm just bad XD).
I think there is a mistake in a calculus question (where the result must be not equal to 4, 18 - 12 = 6 should be a correct answer), but I may have misread something.
A checkpoint system (like every 3 levels) would have helped me reached the end of the game.
Congratulations for putting this together !