I can't see what files the Jiangmin antivirus on VirusTotal seems to have problems with, but it's probably a false positive as I dropped another RPG Maker game in from the Jam (Compound Pr3-G0) and the same flag came up.
The connected domains are interesting, and I can't figure out what's causing them to show up, but they all seem to be legitimate Google/Microsoft domains (only one of the domains is being flagged by one antivirus out of 94). When I launch the game and check the network activity in the resource monitor on my computer, the game doesn't even show up in the list of processes sending or receiving packets. I unfortunately can't check if it's a plugin at work or not causing these domains to appear, because I seem to hit the limit for VirusTotal allowing me to shove entire half-gig zip files at them and none of the plugins are giving flags when uploaded individually, so I can't upload a version of the game without the plugins at the time of this writing. Edit: my best guess right now is that the version of nwjs the game project uses might have some hooks to ping Google for whatever reason (nwjs is built on top of Chromium), but as I've yet to see that activity in my network traffic, the code is probably dormant. Either way, it's harmless.
As for the MetaDefender scan, the flagged file is ffmpeg.dll, which is included in every RPG Maker MV game distribution as part of nwjs and the game literally cannot run without it. It's code that handles and converts media files, which is somewhat necessary for a game made of media files like pictures and sounds. I don't mess with these dll files other than standard version updates to nwjs as a whole directly from the website.