right now it's all speculation. itchio's been facing pressure from payment processors over NSFW content and, god forbid, might be banning it.
Another thing is that the deadline for some puritanical UK policy is coming up soon, so this might be a temporary hiccup until they implement UK specific restrictions.
Problem is though, a lot of games have straight up gotten taken down, especially ones with... close familial relationships. I personally think the total NSFW delisting is temporary, but they're permanently implementing more strict content policy. it's a real letdown.