Thanks again for the replies :)
For the 3rd point, you also have some scaling "transformation" afflictions that you can get with guilt lvl (such as werewolf, necrosis), that feels more like a curse than an upgrade, since you can't remove them easely (only way i found was the baths), but you probably meant it to work that way.
For the 4th point, I'd say that having some kind of advanced option to disable or enable each effects individualy depending on your personnal preferencies would be great, but i don't how feasible it is.