Yeah! That's another one I really want to do. I only recently got into Dune but I think it would work well. My initial thought would be to have a Series Playset called "The Resource" and have it be about trying to gain control of a precious and rare resource. VERY Dune inspired. I'd have to figure out the playbooks for that.
Separately, I was thinking of making a playbook that is essentially a clone or engineered creature called an "Echo" with it being a combo of Bene Gesserit and Tleilaxu. It would have abilities for recalling past memories and stuff like that. It's very early concept, though, but I thought that might be a good way to include some of those themes.