More panty interactions would be neat, sure. I could see that working with the material restraints system to make panties just be a thing that can be worn in different ways, and the exact slot you put them in determines how that works out. Bonus points if you can use that system to remove the panties a girl is already wearing to use them on her elsewhere.
Nurse/Asylum stuff could be a level on its own with very little extra addition... the trick would be making it more interesting than just a reskinned jail. Would involve added medication and hypnosis, presumably? Depends on what exactly the Nurses consider a 'cure' to be...
Kidnappers seem like they'd be a more natural fit for the various improvised bondage materials. In addition to the tape and rope their vendor already sells... anything to do with panty or nylon bondage could easily be a side thing for them.