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Check the quest section in the in-game menu to see what to do.

For "knowing the place" you have to sleep for the first time in the Town Streets, where the girls arrive and then search for a room to sleep, it's the church, if you can't find it you have to defeat the leader in the side street and defeat him with Sapphire.

And "Open for business " the sassafras plant is on the sums behind a wooden plank in the wall, you have to remove it as Sapphire and for the chicken flavoring it's on the commercial district in the restaurant, as Cassiel you have to enter to the kitchen and you will see a shine right next to the chef.