That sounds like a very unique bug actually. Is it only the quicksaves ? can you load /save to the quicksave slots in the GUI ?
It kind of sounds like there is something that hinders you to click the upper part of the screen.
Okay, is the "savegame workaround" in the gameplay settings enable or disabled on your machine ?
The difference is that when the Save game workaround is disabled , then the game will try to save the saved games files onto the system (the files i mentioned earlier) and load from it.
But, if the savegame workaround is enabled , the game tries to use the playerpref variables (mostly hidden in the registery of windows) to save and load the savgames.