I see that we can edit skin textures before starting a playthrough. But I don't see any way to do it after you've started a playthrough and want to change skin textures on a specific loaded save. Is this something that isn't possible?

Floppy ragdoll rpg sandbox with physics-based combat · By
We know the game front and back. The player-texture UI is gone after you start the game.
But, what are you trying to salvage with the game save? With console commands, you can quickly spawn everything back:
Set all 77
Set juice 99999999
spawn (weapon1, weapon2, etc)
Use the 'spawnlist' command to see how to name the things you want to restore.